I think Matt Helm already went here... Or was that Austin Powers? Okay, not, neither. Indiana Jones 4 went here, and it was a disaster... But only because of the writing. I don't know... Am I wrong that scripts just aren't as strong as they used to be?
But yeah. Is the world running out of super, meglomaniac villains? Is there a Bigelow type character that wants to open a portal at Skinwalker ranch and flood the world with the wrong sort of interdimensional aliens? Would they send Bond? Would he be skeptical, having to overcome his own bias, or would he already be in the know because Q got his ideas from a secret stash of mysterious tech?